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ADAM9信息

英文名称:Disintegrin and metalloproteinase domain-containing protein 9
中文名称
靶点别称:Meltrin-gamma,ADAM Metallopeptidase Domain 9 (Meltrin Gamma),Cellular disintegrin-related protein,ADAM 9,Metalloprotease/disintegrin/cysteine-rich protein 9,Mltng,MDC9,KIAA0021,Meltrin Gamma,CORD9,A Disintegrin And Metalloproteinase Domain 9 (Meltrin Gamma),ADAM Metallopeptidase Domain 9,Cone Rod Dystrophy 9,MCMP,Myeloma cell metalloproteinase
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

ADAM9产品列表

ACRO质量管理体系
 
评论(4)
AD9-C52H7|Cynomolgus ADAM9 Protein, His Tag (active enzyme)
  1. 136XXXXXXX5
  2. 3人赞
  3. 长期老顾客,买了无数次了,多种高质量蛋白,用于linker实验,得到了很好的研究,满足抗体制备.希望一直保持下去
  4. 2022-06-17
AD9-H52H7|Human ADAM9 Protein, His Tag (active enzyme)
  1. 181XXXXXXX2
  2. 0人赞
  3. 采购的该蛋白,用于小鼠免疫,4免之后,有非常好的免疫效价;同时也用来做亲和力检测,与对标药物以及我们的内研抗体,都是有非常不错的结合的。唯一的建议是,可以尝试冻干粉形式,现有溶液的浓度稍微低一些,免疫小鼠注射体积会多一些。
  4. 2023-01-30
AD9-H52H7|Human ADAM9 Protein, His Tag (active enzyme)
  1. 156XXXXXXX8
  2. 0人赞
  3. 购买该蛋白用于动物免疫,经过三轮免疫,尾血检测已经能够达到融合要求,而且筛选得到的抗体还能够结合过表达的细胞系。
  4. 2024-03-15
 

ADAM9分子别名

Disintegrin and metalloproteinase domain-containing protein 9 (EC:3.4.24.-) Cellular disintegrin-related protein,Meltrin-gamma,Metalloprotease,disintegrin,cysteine-rich protein 9,Myeloma cell metalloproteinase,ADAM9,KIAA0021, MCMP, MDC9, MLTNG

ADAM9分子背景

ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin domain for adhesion and the metalloprotease domain for ectodomain shedding of a wide variety of cell surface proteins. ADAM9 influences the developmental process, inflammation, and degenerative diseases.Recently, increasing evidence has shown that ADAM9 plays an important role in tumor biology. Overexpression of ADAM9 has been found in several cancer types and is correlated with tumoraggressiveness and poor prognosis. In addition, through either proteolytic or non-proteolytic pathways, ADAM9 promotes tumor progression, therapeutic resistance, and metastasis of cancers.Therefore, comprehensively understanding the mechanism of ADAM9 is crucial for the development of therapeutic anti-cancer strategies. In this review, we summarize the current understanding of ADAM9 in biological function, pathophysiological diseases, and various cancers. Recent advances in therapeutic strategies using ADAM9-related pathways are presented as well.

ADAM9临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Izeltabart tapatansine IMGC-936 临床二期 Immunogen Inc 实体瘤 详情

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