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CCL2信息

英文名称:C-C motif chemokine 2
中文名称:C-C基序趋化因子-2
靶点别称:MCP1,HC11,Monocyte chemotactic protein 1,Monocyte chemoattractant protein 1,CCL2,C-C Motif Chemokine Ligand 2,Monocyte Chemotactic And Activating Factor,Monocyte Secretory Protein JE,Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je),Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2,Monocyte Chemoattractant Protein-1,Chemokine (C-C Motif) Ligand 2,Small-Inducible Cytokine A2,SCYA2,MCP-1,MCAF,Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je,C
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

CCL2产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CC2-H5255
Human
Human CCL2 / MCP-1 Protein, Fc Tag (MALS verified)
 
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CCL2 分子别名

CCL2/C-C motif chemokine 2/MCP-1/MCAF

CCL2 分子背景

Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. CCL2, a member of the CC subfamily, is characterized by two adjacent cysteine residues. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

CCL2 前沿进展

CCL2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AFX-5931 AFX-5931 临床二期 Afecta Pharmaceutical 湿疹 详情

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