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Activin RIIB信息

英文名称:Activin receptor type-2B
中文名称:激活素受体-2B
靶点别称:Activin receptor type IIB,ACVR2B,Activin A Receptor Type 2B,Activin A Receptor, Type IIB,Activin Receptor Type-2B,EC 2.7.11.30,ActR-IIB,ACTRIIB,HTX4,EC 2.7.11,EC:2.7.11.30
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

Activin RIIB产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
ACB-H5226
Human
Human Activin RIIB / ACVR2B Protein, His Tag
 
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Activin RIIB 分子别名

ACVR2B,ACTRIIB,MGC116908

Activin RIIB 分子背景

Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).

Activin RIIB 参考文献

Activin RIIB临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Bimagrumab BYM-338 临床二期 Morphosys Ag, 诺华制药 二型糖尿病, 包涵体肌炎, 慢性阻塞性肺疾病, 肌肉减少症 详情
BIIB-110 ALG-801; BIIB-110 临床一期 百健 肌萎缩性侧索硬化, 脊髓性肌萎缩 详情

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