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IL3-H52H9|Human IL-3 Protein, His Tag (MALS verified)
  1. 178XXXXXXX7
  2. 0人赞
  3. 主要用于单克隆抗体的筛选。实验采用了终点法酶联免疫吸附测定抗原抗体之间的相互作用强弱。通过对各个抗体进行亲和力测定来评估抗体的性能,筛选出符合预期的目标抗体。
  4. 2021-12-06
 

IL-3 分子别名

IL3,MCGF,MGC79398,MGC79399,MULTI-CSF,Interleukin-3

IL-3 分子背景

Interleukin 3 is also known as IL-3, is a protein that in humans is encoded by the IL3 gene. Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. It acts by binding to the interleukin-3 receptor. The IL-3 receptor is a heterodimer of the IL-3 specific α-chain and the common β-chain, βc, which is also used by GM-CSF and IL-5. [3] Binding of IL-3 can also involve substitution of the βc by a βIL-3-chain that appears to be specific for IL-3 . Binding of IL-3 to its cognate receptor(s) induces activation of Jak2, phosphorylation of multiple Stats, and the PI3K/Akt pathway. IL-3 may play an important role in the development of airway inflammation associated with asthma. The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF.

IL-3 前沿进展

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