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CCL20信息

英文名称:C-C motif chemokine 20
中文名称:CC类趋化因子20
靶点别称:Chemokine CCL20,Exodus-1,ST38,Chemokine (C-C Motif) Ligand 20,CCL20,LARC,C-C motif chemokine 20,SCYA20,MIP-3-alpha,C-C Motif Chemokine Ligand 20,Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20,Liver And Activation-Regulated Chemokine,Macrophage Inflammatory Protein 3 Alpha,MIP-3a,CKb4,Small-Inducible Cytokine A20,CC Chemokine LARC,MIP3A,Beta Chemokine Exodus-1,Beta-Chemokine Exodus-1,Exodus
上市药物数量:0
临床药物数量:0
最高研发阶段:终止

CCL20产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CC0-M82E5
Mouse
Biotinylated Mouse CCL20 / MIP-3 alpha Protein, His,Avitag™
 
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CCL20 分子别名

C-C motif chemokine 20,Beta-chemokine exodus-1,CC chemokine LARC,Liver and activation-regulated chemokine,Macrophage inflammatory protein 3 alpha,MIP-3-alpha,Small-inducible cytokine A20,CCL20

CCL20 分子背景

C-C motif chemokine 20(CCL20) acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes . Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes.

CCL20 前沿进展

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