CCN family member 1,CCN1,CCN1IGF-binding protein 10,Cyr61,Cysteine-rich angiogenic inducer 61,cysteine-rich,angiogenic inducer,61,GIG1,GIG1cysteine-rich heparin-binding protein 61,IBP-10,IGFBP-10,IGFBP10cysteine-rich, anigogenic inducer, 61,Insulin-like g
Cyr61, also know as Cellular communication network factor 1（CCN1）can promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.