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Activin RIB信息
英文名称：Transforming growth factor beta receptor 1
中文名称：转化生长因子β受体1
靶点别称：EC 2.7.11，TGF-beta type I receptor，Serine/threonine-protein kinase receptor R4，TGFBR1，Activin A receptor type II-like protein kinase of 53kD，Transforming Growth Factor Beta Receptor 1，Transforming Growth Factor-Beta Receptor Type I，Activin A Receptor Type II-Like Kinase， 53kDa，Activin Receptor-Like Kinase 5，TGFR-1，ALK-5，ALK5，SKR4，Mutant Transforming Growth Factor Beta Receptor I，TGF-Beta Receptor Type-1，TGF-Beta Receptor Type I，EC 2.7.11.30，ACVRLK4，LDS1A，LDS2A，AAT5，LDS1，TBRI，ESS1，MSSE，TbetaR-I，T
中文名称：转化生长因子β受体1
靶点别称：EC 2.7.11，TGF-beta type I receptor，Serine/threonine-protein kinase receptor R4，TGFBR1，Activin A receptor type II-like protein kinase of 53kD，Transforming Growth Factor Beta Receptor 1，Transforming Growth Factor-Beta Receptor Type I，Activin A Receptor Type II-Like Kinase， 53kDa，Activin Receptor-Like Kinase 5，TGFR-1，ALK-5，ALK5，SKR4，Mutant Transforming Growth Factor Beta Receptor I，TGF-Beta Receptor Type-1，TGF-Beta Receptor Type I，EC 2.7.11.30，ACVRLK4，LDS1A，LDS2A，AAT5，LDS1，TBRI，ESS1，MSSE，TbetaR-I，T
上市药物数量：0
临床药物数量：6
最高研发阶段：临床三期
临床药物数量：6
最高研发阶段：临床三期
Activin RIB产品列表
| 货号 | 物种 | 产品描述 | 蛋白结构 | 纯度 | 活性 |
|---|---|---|---|---|---|
| ACB-H52H4 |
 Human |
Human Activin RIB / ACVR1B Protein, His Tag |
 |
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Activin RIB 分子别名
ACVR1b,ALK4,ACVRLK4,ACTR-IB,SKR2
Activin RIB 分子背景
Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.
Activin RIB 前沿进展
Activin RIB临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| AVID-200 | AVID-200 | 临床一期 | Formation Biologics | 实体瘤, 系统性硬皮病, 骨髓纤维化, 弥漫性硬皮病 | 详情 |
| PF-06952229 | 临床一期 | 辉瑞 | 肝癌, 肾细胞癌, 鳞状细胞肿瘤, 胰腺癌, 间皮组织肿瘤, 乳腺癌, 前列腺癌, 结直肠癌, 黑色素瘤 | 详情 | |
| 奥欣色替 | SH-3051 | 临床一期 | 南京圣和药业股份有限公司 | 肝癌, 实体瘤 | 详情 |
| TRK-250 | TRK-250; BNC-1021 | 临床一期 | Bonac Corp | 特发性肺纤维化 | 详情 |
| Galunisertib | LY-2157299 | 临床三期 | 礼来制药 | 实体瘤, 肝癌, 骨髓增生异常综合征, 胶质母细胞瘤, 胰腺癌, 胶质瘤, 肝细胞癌, 转移癌, 非小细胞肺癌 | 详情 |
| ORG-129 | ORG-129 | 临床一期 | 克罗恩病 | 详情 | |
| GF-101 | GFH018; GFH-018; GF-101 | 临床二期 | 劲方医药科技（上海）有限公司 | 实体瘤, 肝癌, 移行细胞癌, 胰腺癌 | 详情 |
