Activin RIB 靶点蛋白|抗体药物|临床药物信息

Activin RIB信息

英文名称：Transforming growth factor beta receptor 1
中文名称：转化生长因子β受体1
靶点别称：EC 2.7.11，TGF-beta type I receptor，Serine/threonine-protein kinase receptor R4，TGFBR1，Activin A receptor type II-like protein kinase of 53kD，Transforming Growth Factor Beta Receptor 1，Transforming Growth Factor-Beta Receptor Type I，Activin A Receptor Type II-Like Kinase， 53kDa，Activin Receptor-Like Kinase 5，TGFR-1，ALK-5，ALK5，SKR4，Mutant Transforming Growth Factor Beta Receptor I，TGF-Beta Receptor Type-1，TGF-Beta Receptor Type I，EC 2.7.11.30，ACVRLK4，LDS1A，LDS2A，AAT5，LDS1，TBRI，ESS1，MSSE，TbetaR-I，T

上市药物数量：0
临床药物数量：8
最高研发阶段：临床二期

Activin RIB产品列表

筛选结果

产品库

在线 (1)

物种

Human (1)

标签

His Tag (1)

属性

Protein (1)

标记

Unconjugated (1)

货号	物种	产品描述	蛋白结构	纯度	活性
ACB-H52H4	Human	Human Activin RIB / ACVR1B Protein, His Tag

Activin RIB 分子别名

ACVR1b,ALK4,ACVRLK4,ACTR-IB,SKR2

Activin RIB 分子背景

Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.

Activin RIB 前沿进展

Activin RIB临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Itacnosertib	TP-0184	临床二期	Tolero Pharmaceuticals Inc, 大日本住友	实体瘤, 贫血, 肿瘤	详情
GF-101	GFH-018; GF-101; GFH018	临床二期	劲方医药科技（上海）有限公司	肝癌, 实体瘤, 胰腺癌, 尿路上皮癌, 非小细胞肺癌	详情
Galunisertib	LY-2157299	临床二期	礼来制药	胰腺癌, 非小细胞肺癌, 转移癌, 肝细胞癌, 胶质瘤, 结直肠癌, 前列腺癌, 鼻咽癌, 乳腺癌, 肝癌, 胶质母细胞瘤, 骨髓增生异常综合征, 三阴性乳腺癌, 肿瘤, 直肠癌, 肾细胞癌, 实体瘤	详情
奥欣色替	SH-3051	临床一期	南京圣和药业股份有限公司	肝癌, 实体瘤	详情
TD-1058		临床一期	Theravance Biopharma Inc	特发性肺纤维化	详情
TRK-250	TRK-250; BNC-1021	临床一期	Bonac Corp	特发性肺纤维化	详情
ORG-129	ORG-129; AGMB-129	临床一期	Origo Biopharma Sociedad Litmitada	克罗恩病	详情

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Activin RIB