Recombinant Proteins iso9001 ISO13485
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 > 【Activin RIB】重组蛋白信息

Activin RIB信息

英文名称:Transforming growth factor beta receptor 1
中文名称:转化生长因子β受体1
靶点别称:EC 2.7.11,TbetaR-I,TGF-beta type I receptor,Serine/threonine-protein kinase receptor R4,TGFBR1,Activin A receptor type II-like protein kinase of 53kD,Transforming Growth Factor Beta Receptor 1,Transforming Growth Factor-Beta Receptor Type I,Activin A Rece
上市药物数量:0
临床药物数量:5
最高研发阶段:临床三期

Activin RIB产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
ACB-H52H4
Human
Human Activin RIB / ACVR1B Protein, His Tag
 
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Activin RIB Molecule Synonym Name

ACVR1b,ALK4,ACVRLK4,ACTR-IB,SKR2

Activin RIB 分子背景

Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.

Activin RIB 参考文献

Activin RIB临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AVID-200 AVID-200 临床一期 Formation Biologics 肿瘤, 系统性硬皮病, 骨髓纤维化, 弥漫性硬皮病 详情
PF-06952229 临床一期 辉瑞 肝癌, 肾细胞癌, 鳞状细胞肿瘤, 胰腺癌, 间皮组织肿瘤, 乳腺癌, 前列腺癌, 结直肠癌, 黑色素瘤 详情
TRK-250 TRK-250; BNC-1021 临床一期 Bonac Corp 特发性肺纤维化 详情
GFH-018 GFH018; GFH-018 临床一期 劲方医药科技(上海)有限公司 肝癌, 实体瘤, 胰腺癌, 移行细胞癌
Galunisertib LY-2157299 临床三期 礼来制药 实体瘤, 肝癌, 骨髓增生异常综合征, 胶质母细胞瘤, 胰腺癌, 胶质瘤, 肝细胞癌, 转移癌, 非小细胞肺癌 详情

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