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IL-27信息

英文名称:Interleukin-27
中文名称:白细胞介素-27
靶点别称:IL27,Interleukin-27,Interleukin 27,IL-27A,IL-27
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

IL-27产品列表

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IL-27分子别名

p28,IL30,IL-27,IL-27A,IL27p28,Interleukin-27,EBI3

IL-27分子背景

Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-30). IL-27 is produced by antigen-presenting cells. IL-27 plays an important function in regulating the activity of B and T lymphocytes. The effects of IL-27 are eliciting by its interaction with a specific cell surface receptor complex composed of two proteins known as IL27R and gp130. IL-27 is a cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T cells. Another important role of IL-27 is its antitumor activity and antiangiogenic activity.

IL-27临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Casdozokitug SRF-388 临床二期 Surface Oncology Inc 实体瘤, 肾细胞癌, 肝细胞癌, 非小细胞肺癌 详情

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