TSPAN8 靶点蛋白|抗体药物|临床药物信息

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在线 (4)

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His Tag (4)

属性

Protein (4)

标记

Unconjugated (4)

货号	物种	产品描述
TS8-H52H3	Human	Human TSPAN8 Protein, His Tag
TS8-C5248	Canine	Canine TSPAN8 Protein, His Tag (MALS verified)
TS8-C5247	Cynomolgus	Cynomolgus TSPAN8 Protein, His Tag
TS8-M5249	Mouse	Mouse TSPAN8 Protein, His Tag (MALS verified)

TSPAN8 分子别名

CO-029,tetraspanin 8,TM4SF3,TM4SF3tspan-8,Transmembrane 4 superfamily member 3tetraspanin-8,TSPAN8,Tspan-8,Tumor-associated antigen CO-029

TSPAN8 分子背景

Tspan8 is 1 of the 33 mammalian members of the tetraspanin family, composed of transmembrane proteins that organize laterally, together or with other membrane partners such as integrins, to form ‘tetraspanin webs’. These platforms signal within cells to regulate many cellular processes: adhesion, migration, invasion or survival Tspan8 has been implicated in many types of cancer.Overexpression was reported in glioma and colorectal, esophageal, hepatic, gastric and pancreatic carcinoma. Tspan8 exerts a pro-invasive function by controlling cell–cell and cell–matrix interactions through its association with membrane partners such as α6β4 integrin-protein kinase C (PKC)-activated, E-cadherin, EpCAM, claudin-7 and CD44. Moreover, Tspan8 may be a promising new therapeutic target, as Tspan8-specific antibodies were shown to reduce cell motility, block tumor angiogenesis in vivo.

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