Thrombopoietin 分子别名
Thrombopoietin,MKCSF,THPO,TPO,C-mpl ligand,MGDF
Thrombopoietin 分子背景
Thrombopoietin (TPO) is a 332 amino acid glycoprotein made primarily in the liver and act as the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. Additionally, further investigation uncovered that thrombopoietin is a critical cytokine promoting hematopoietic rebound after myeloablation and its transcripts are expressed by multiple cellular sources.
Thrombopoietin 前沿进展