CRTAM 靶点蛋白|抗体药物|临床药物信息

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Protein (2)

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Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
CRM-C5255	Cynomolgus	Cynomolgus CRTAM Protein, Fc Tag
CRM-H52H3	Human	Human CRTAM Protein, His Tag

CRTAM 分子别名

CRTAM,CD355

CRTAM 分子背景

Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.

CRTAM 前沿进展

Arase N., et al., 2005, Int. Immunol. 17:1227.

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