B7-1 靶点蛋白|抗体药物|临床药物信息

B7-1信息

英文名称：Cluster of differentiation 80
中文名称：分化群80
靶点别称：Activation B7-1 antigen，LAB7，T-lymphocyte activation antigen CD80，CD80 Molecule，CD80 Antigen (CD28 Antigen Ligand 1， B7-1 Antigen)，B-Lymphocyte Activation Antigen B7，CTLA-4 Counter-Receptor B7.1，CD28LG1，BB1，Costimulatory Molecule Variant IgV-CD80，Costimulatory Factor CD80，CD80 Antigen，B7-1，B7.1，B7-1 Antigen，B7，CD80，CD28LG

上市药物数量：2
临床药物数量：5
最高研发阶段：批准上市

B7-1产品列表

筛选结果

产品库

在线 (11)

物种

标签

属性

Protein (11)

标记

货号	物种	产品描述
B71-H82F2	Human	Biotinylated Human B7-1 / CD80 Protein, Fc,Avitag™ (MALS verified)
B71-H5228	Human	Human B7-1 / CD80 Protein, His Tag (MALS verified)
B71-H52A4	Human	Human B7-1 / CD80 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
B71-H5259	Human	Human B7-1 / CD80 Protein, Fc Tag (MALS verified)
B71-H82E9	Human	Biotinylated Human B7-1 / CD80 Protein, Avitag™,His Tag (recommended for biopanning)
B71-H82F3	Human	Biotinylated Human B7-1 / CD80 Protein, Fc,Avitag™ (MALS verified)
B71-R52H9	Rat	Rat B7-1 / CD80 Protein, His Tag
CD0-C5252	Cynomolgus / Rhesus macaque	Cynomolgus / Rhesus macaque B7-1 / CD80 Protein, Fc Tag (MALS verified)
CD0-C52H3	Cynomolgus / Rhesus macaque	Cynomolgus / Rhesus macaque B7-1 / CD80 Protein, His Tag (MALS verified)
CD0-M5228	Mouse	Mouse B7-1 / CD80 Protein, His Tag
CD0-M5259	Mouse	Mouse B7-1 / CD80 Protein, Fc Tag (MALS verified)

B71-H82F2|Biotinylated Human B7-1 / CD80 Protein, Fc,Avitag™ (MALS verified)

135XXXXXXX2

4人赞

在贵公司购买了这个CD80蛋白用来做elisa，筛选纯化后的单抗，做了阻断IC50实验，每次实验结果都能筛选出不同阻断效果的单抗，效果不错，经过蛋白电泳验证，结果显示稳定性也很好，很不错的一款产品。
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2021-09-01

B71-H5228|Human B7-1 / CD80 Protein, His Tag (MALS verified)

182XXXXXXX2

4人赞

运用Acro家的B7-1与别家的CD28做BIL实验，亲和力不错，拟合结果相当好，R2达到了0.997，不错的产品。
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2020-01-10

B71-H5228|Human B7-1 / CD80 Protein, His Tag (MALS verified)

152XXXXXXX2

3人赞

使用过该蛋白做ELISA实验，将该CD80蛋白包被到孔板中，然后加入抗体分子与biotin-PDL1做blocking assay，可以获得理想的数据。
>
2019-10-12

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B7-1分子别名

CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7

B7-1分子背景

B7-1 and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with a 20 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response.
B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

B7-1上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
Abatacept	阿巴西普	BMS-188667SC; ONO-4164; BMS-188667; ONO-4164SC	批准上市	百时美施贵宝	Orencia, 恩瑞舒	United States	移植物抗宿主病	Bristol Myers Squibb Srlcompany	2005-12-23	溃疡性结肠炎, 关节炎, 普通可变性免疫缺陷, 葡萄膜炎, 心脏和血管疾病, 哮喘, 银屑病关节炎, Sjogren-Larsson综合征, 荨麻疹, 弥漫性硬皮病, 银屑病, 大动脉炎, 局灶性节段性肾小球硬化症, 再生障碍性贫血, 系统性红斑狼疮, Shwachman-Diamond综合征, 间质性肺疾病, 多发性硬化, 肾病综合征, 肌病, 眼部疾病, 慢性肉芽肿病, 噬血细胞性淋巴组织细胞增多症, 关节痛, 心肌炎, 白细胞粘附缺陷综合征, 炎性疾病, 白癜风, 镰状细胞血症, 血小板机能不全, Kostmann综合征, 克罗恩病, 白塞病综合征, 移植物抗宿主病, 复发性多软骨炎, 抗中性粒细胞胞浆抗体相关性血管炎, 重症肌无力, 多发性肌炎, 威斯科特-奥尔德里奇综合征, 血液疾病, 一型糖尿病, 复发-缓解型多发性硬化, 斑秃, 肌炎, 皮肌炎, 巨细胞性动脉炎, 免疫球蛋白G4相关疾病, 类风湿关节炎, Chediak-Higashi综合征, 韦格纳肉芽肿, 强直性	详情
Belatacept		LEA29Y; LEA-029; BMS-224818; L104EA29YIg	批准上市	百时美施贵宝	Nulojix	EU	肾脏移植排斥	Bristol-Myers Squibb Pharma Eeig	2011-06-15	肾脏移植排斥, 一型糖尿病, 类风湿关节炎, 胰腺神经内分泌肿瘤, 蛋白尿, 器官移植排斥, 移植物功能延迟恢复, 心脏移植排斥, 终末期肾脏病	详情

B7-1临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Chimeric antigen receptor T-cell therapy (Hunan Zhaotai Yongren Biotech)	Z-CTLs	临床一期	湖南昭泰涌仁生物科技有限公司	非小细胞肺癌	详情
ORCA-010	ORCA-010	临床二期	Orca Therapeutics Bv	前列腺癌	详情
Membrane bound ligand T-SIGn virus	NG-348	临床一期	Psioxus Therapeutics Ltd	肿瘤	详情
Belatacept biosimilar (Alphamab)	KN-019	临床二期	苏州康宁杰瑞生物科技有限公司	肾脏移植排斥, 类风湿关节炎	详情
Recombinant human CTLA-4-FC fusion protein(Beijing Vdjbio)		临床一期	北京伟德杰生物科技有限公司	类风湿关节炎	详情

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B7-1