Fusion glycoprotein 靶点蛋白|抗体药物|临床药物信息

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Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
FUN-N52H3	Nipah virus	Nipah virus Fusion glycoprotein, His Tag
FUN-H52H4	Hendra virus	Hendra virus Fusion glycoprotein (A263T), His Tag

Fusion glycoprotein 分子别名

Fusion glycoprotein, F protein, F, Nipah virus, Hendra virus

Fusion glycoprotein 分子背景

Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses discovered in the mid-to late 1990s that possess a broad host tropism and are known to cause severe and often fatal disease in both humans and animals. HeV and NiV infect host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. G is a type II homotetrameric transmembrane protein responsible for binding to ephrinB2 or ephrinB3 (ephrinB2/B3) receptors. F is a homotrimeric type I transmembrane protein that is synthesized as a premature F0 precursor and cleaved by cathepsin L during endocytic recycling to yield the mature, disulfide-linked, F1 and F2 subunits. Upon binding to ephrinB2/B3, NiV G undergoes conformational changes leading to F triggering and insertion of the F hydrophobic fusion peptide into the target membrane. Subsequent refolding into the more stable post-fusion F conformation drives merger of the viral and host membranes to form a pore for genome delivery to the cell cytoplasm.

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Fusion glycoprotein

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