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Ly6E信息

英文名称:Lymphocyte antigen 6E
中文名称:淋巴细胞抗原-6
靶点别称
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

Ly6E产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
 
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Ly6E 分子别名

LY6E,Ly-6E,Ly6E,RIG-E,SCA-2,TSA-1,9804,RIGE,SCA2,TSA1

Ly6E 分子背景

Lymphocyte antigen 6E (LY6E), also known as RIG-E, SCA2 and TSA1. GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.

Ly6E 前沿进展

Ly6E临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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