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IL-13 R alpha 1信息

英文名称:Interleukin-13 receptor subunit alpha-1
中文名称:白介素-13受体α1亚基
靶点别称:IL-13 receptor subunit alpha-1,IL-13R subunit alpha-1,IL-13R-alpha-1,IL-13RA1,Cancer/testis antigen 19,CD213a1,Interleukin 13 Receptor Subunit Alpha 1,CD213a1 Antigen,Interleukin-13 Receptor Subunit Alpha-1,Interleukin 13 Receptor, Alpha 1,IL-13 Receptor Subunit Alpha-1,IL13 Receptor Alpha-1 Chain,Cancer/Testis Antigen 19,IL-13R Subunit Alpha-1,IL-13Ra,NR4,IL-13R-Alpha-1,CD213A1,IL13RA1,IL13RA
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

IL-13 R alpha 1 分子别名

IL13RA1,CD213A1,IL-13Ra,NR4,RP13-128O4.2,IL13Rα1

IL-13 R alpha 1 分子背景

Interleukin 13 receptor, alpha 1 is also known as IL13RA1, NR4 and CD213A1 (cluster of differentiation 213A1), The IL13 Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. Human and mouseIL13Rα1 share 76% aa sequence identity. IL13RA1 is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.

IL-13 R alpha 1 前沿进展

IL-13 R alpha 1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Eblasakimab MK-6105; ASLAN-004; CSL-334 临床二期 Csl Ltd, 默沙东 特应性皮炎, 超敏反应 详情

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