Recombinant Proteins iso9001 ISO13485
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 > 【Fas Ligand】重组蛋白信息

Fas Ligand信息

英文名称:Soluble Fas ligand
中文名称:可溶性Fas配体
靶点别称:CD95L,Fas ligand,SPA,FASLG,Soluble Fas ligand,sFasL,Receptor-binding FasL ectodomain,FasL ICD,TNFSF6,Apoptosis antigen ligand,Tumor necrosis factor ligand superfamily member 6,APL,CD178,Fas Ligand (TNF Superfamily, Member 6),Fas Antigen Ligand,CD95 Ligand
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

Fas Ligand产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
FAL-H5241
Human
Human Fas Ligand / TNFSF6 Protein, His Tag, active trimer (MALS verified)
 
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Fas Ligand 分子别名

FASLG,ALPS1B,APT1LG1,CD178,CD95L,FASL,TNFSF6

Fas Ligand 分子背景

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

Fas Ligand 参考文献

Fas Ligand临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Asunercept CAN-008; APG-101 临床二期 Apogenix 胶质母细胞瘤, 骨髓增生异常综合征, 新型冠状病毒肺炎 详情

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