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> 【GDF-8】
GDF-8信息
英文名称：Growth/differentiation factor 8
中文名称：生长分化因子-8
靶点别称：MSTN，GDF-8，GDF8，Growth Differentiation Factor 8，MSLHP，Myostatin，Growth/Differentiation Factor 8
中文名称：生长分化因子-8
靶点别称：MSTN，GDF-8，GDF8，Growth Differentiation Factor 8，MSLHP，Myostatin，Growth/Differentiation Factor 8
上市药物数量：0
临床药物数量：4
最高研发阶段：临床三期
临床药物数量：4
最高研发阶段：临床三期
GDF-8 分子别名
GDF-8, Myostatin, GDF8, MSTN, Growth/differentiation factor 8
GDF-8 分子背景
Growth differentiation factor 8 (GDF8), also known as myostatin, is a unique member of the transforming growth factor-β superfamily that is expressed in human granulosa cells and has important roles in regulating a variety of ovarian functions. GDF8 acts as a negative regulator of skeletal muscle growth and differentiation. In addition to the expression in the musculoskeletal system, GDF8 is also expressed in various tissues, including the reproductive system.
GDF-8 前沿进展
GDF-8临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| AAV1-FS344 | AAV1-Follistatin; AAV1-FS344 | 临床二期 | Nationwide Children'S Hospital | 包涵体肌炎, 杜氏肌营养不良症 | 详情 |
| RO-7204239 | GYM-329; RO-7204239; RG-6237; RG-70240 | 罗氏, 中外制药株式会社 | 详情 | ||
| Ramatercept | ACE-031; RAP-031; HGT-4510 | Acceleron | 详情 | ||
| Apitegromab | SRK-015 | Scholar Rock | 详情 | ||
| Domagrozumab | PF-6252616; PF-06252616 | 辉瑞 | 详情 | ||
| Talditercept alfa | RO-7239361; BMS-986089; RG-6206; BHV-2000 | 临床三期 | 百时美施贵宝 | 杜氏肌营养不良症, 神经肌肉疾病, 脊髓性肌萎缩 | 详情 |
