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Angiopoietin-1信息

英文名称:Angiopoietin-1
中文名称:血管生成素-1
靶点别称:KIAA0003,ANGPT1,Angiopoietin 1,ANG-1,AGP1,AGPT,ANG1,Angiopoietin-1
上市药物数量:0
临床药物数量:4
最高研发阶段:临床三期

Angiopoietin-1产品列表

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Angiopoietin-1 分子别名

ANGPT1,AGP1,AGPT,ANG1,Angiopoietin-1

Angiopoietin-1 分子背景

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

Angiopoietin-1 前沿进展

Angiopoietin-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
DBPR-114 DBPR-114 临床一期 National Health Research Institutes 肿瘤 详情
Trebananib AMG-386; 20060439 安进, Takeda Pharmaceutical Co Ltd 详情
Recombinant NAPc2 AB-201 临床三期 Dendreon Uk Ltd 新型冠状病毒肺炎 详情

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