Dkk-1 靶点蛋白|抗体药物|临床药物信息

Dkk-1信息

英文名称：Dickkopf-related protein 1
中文名称：Dickkopf相关蛋白-1
靶点别称：Dickkopf-Like Protein 1，Dickkopf 1 Homolog，Dickkopf-1 Like，Dickkopf-1，Dkk-1，UNQ492/PRO1008，Dickkopf-related protein 1，hDkk-1，SK，DKK1，Dickkopf WNT Signaling Pathway Inhibitor 1，Dickkopf 1 Homolog (Xenopus Laevis)，Dickkopf (Xenopus Laevis) Homolog 1

上市药物数量：0
临床药物数量：2
最高研发阶段：临床二期

Dkk-1产品列表

筛选结果

产品库

在线 (4)

物种

标签

属性

Protein (4)

标记

货号	物种	产品描述
DK1-H5221	Human	ActiveMax® Human Dkk-1 Protein, His Tag (MALS verified)
DK1-H82F5	Human	Biotinylated Human Dkk-1 Protein, Fc,Avitag™
DK1-H5258	Human	Human Dkk-1 Protein, Fc Tag (MALS verified)
DK1-M52H6	Mouse	Mouse Dkk-1 Protein, His Tag

Dkk-1 分子别名

DKK1,SK

Dkk-1 分子背景

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

Dkk-1 前沿进展

Dkk-1临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Sirexatamab	DKN-01; LY-2812176	临床二期	礼来制药	卵巢癌, 肝癌, 实体瘤, 胃癌, 食道癌, 多发性骨髓瘤, 胆管上皮癌, 胆道癌, 结直肠癌, 子宫肿瘤, 子宫内膜癌, 癌肉瘤, 胆囊癌, 非小细胞肺癌, 肝细胞癌	详情
JS-015	JS-015	临床一期	上海君实生物工程有限公司	实体瘤	详情

会议日历

会议一览

Dkk-1