MARCO 靶点蛋白|抗体药物|临床药物信息

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在线 (4)

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His Tag (4)

属性

Protein (4)

标记

Unconjugated (4)

货号	物种	产品描述
MAR-C5248	Cynomolgus	Cynomolgus MARCO Protein, His Tag
MAR-M5245	Mouse	Mouse MARCO Protein, His Tag
MAR-H5243	Human	Human MARCO Protein, His Tag
MAR-M5246	Mouse	Mouse MARCO (421-518) Protein, His Tag

MARCO 分子别名

MARCO, SCARA2, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2

MARCO 分子背景

MARCO is also known as Scavenger receptor class A member 2 and SCARA2. Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2. MARCO ligation promotes the production of inflammatory mediators by macrophages. MARCO mediated internalization of some ligands prevents their activation of cell surface TLR4 but enables their activation of intracellular TLR3. MARCO contributes to the clearance of apoptotic cells and inhaled bacteria, mast cell mediated silicosis, and the amelioration of allergen or ozone induced lung inflammation. It is required for the organization of the splenic marginal zone and the interaction of splenic macrophages and B cells.

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