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LGR5信息

英文名称:Leucine-rich repeat-containing G-protein coupled receptor 5
中文名称:富含亮氨酸重复序列的G蛋白偶联受体-5
靶点别称:FEX,G Protein-Coupled Receptor 49,GRP49,HG38,G-protein coupled receptor HG38,GPR49,GPR67,G-protein coupled receptor 49,Leucine-rich repeat-containing G-protein coupled receptor 5,LGR5,Leucine Rich Repeat Containing G Protein-Coupled Receptor 5,G-Protein Coupled Receptor 67,Orphan G Protein-Coupled Receptor HG38
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

LGR5产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
LG5-C52H7
Cynomolgus
Cynomolgus LGR5 / GPR49 protein, His Tag
LG5-H52H3
Human
Human LGR5 / GPR49 protein, His Tag
ACRO质量管理体系
 
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LGR5分子别名

LGR5, GPR49, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, Leucine-rich repeat-containing G-protein coupled receptor 5

LGR5分子背景

LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.

LGR5临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CNA-3103 CNA-3103 临床二期 Carina Biotech Pty Ltd 结直肠癌 详情
Petosemtamab MCLA-158 临床二期 Merus Nv 食道癌, 头颈部鳞状细胞癌, 胃癌, 肿瘤, 结直肠癌, 非小细胞肺癌 详情

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