登录 | 注册    关注公众号  
搜索
 > 【LGR5】

LGR5信息

英文名称:Leucine-rich repeat-containing G-protein coupled receptor 5
中文名称:富含亮氨酸重复序列的G蛋白偶联受体-5
靶点别称:FEX,G Protein-Coupled Receptor 49,GRP49,HG38,G-protein coupled receptor HG38,GPR49,GPR67,G-protein coupled receptor 49,Leucine-rich repeat-containing G-protein coupled receptor 5,LGR5,Leucine Rich Repeat Containing G Protein-Coupled Receptor 5,G-Protein Coupled Receptor 67,Orphan G Protein-Coupled Receptor HG38
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

LGR5产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
LG5-H52H3
Human
Human LGR5 / GPR49 protein, His Tag
 
评论(0)
 

LGR5 分子别名

LGR5, GPR49, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, Leucine-rich repeat-containing G-protein coupled receptor 5

LGR5 分子背景

LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.

LGR5 前沿进展

LGR5临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Petosemtamab MCLA-158 临床一期 Merus 结直肠癌 详情

消息提示

请输入您的联系方式,再点击提交!

确定