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TGF-beta 3信息

英文名称:Transforming growth factor beta 3
中文名称:转化生长因子β3
靶点别称:Transforming Growth Factor beta3,TGFB3,LAP,Prepro-Transforming Growth Factor Beta-3,TGF-Beta3,Transforming Growth Factor, Beta 3,ARVD1,LDS5,Arrhythmogenic Right Ventricular Dysplasia 1,RNHF,Transforming growth factor beta-3 proprotein,ARVD
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

TGF-beta 3 分子别名

TGFB3,ARVD,TGF-beta3

TGF-beta 3 分子背景

Transforming growth factor beta 3 ( TGFB3) is also known as TGF-β3, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. TGF-beta 3 is similar with TGF-beta 1 and ­-beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial­-mesenchymal transition. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.

TGF-beta 3 前沿进展

TGF-beta 3临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AVID-200 AVID-200 临床一期 Formation Biologics 实体瘤, 系统性硬皮病, 骨髓纤维化, 弥漫性硬皮病 详情

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