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SIRP alphaV8产品列表

 
评论(1)
SI8-H82W6|Biotinylated Human SIRP alphaV8 / CD172a Protein, His,Avitag™
  1. 136XXXXXXX5
  2. 0人赞
  3. 筛选抗体,主要用于抗体的竞争活性实验(Elisa),实验结果符合自己的预期,得到了比较满意的结果!期待以后能有更多的产品应用于实验
  4. 2021-09-26
 

SIRP alphaV8 分子别名

SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1

SIRP alphaV8 分子背景

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

SIRP alphaV8 前沿进展

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