NCAM-1 靶点蛋白|抗体药物|临床药物信息

NCAM-1信息

英文名称：Neural cell adhesion molecule 1
中文名称：神经细胞粘附分子-1
靶点别称：Neural cell adhesion molecule 1，CD56，NCAM1，NCAM，Neural Cell Adhesion Molecule， NCAM，CD56 Antigen，N-CAM-1，MSK39，NCAM-1，Antigen Recognized By Monoclonal Antibody 5.1H11

上市药物数量：0
临床药物数量：2
最高研发阶段：临床二期

NCAM-1产品列表

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在线 (6)

物种

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属性

Protein (6)

标记

货号	物种	产品描述
NC1-H5223	Human	Human NCAM-1 / CD56 Protein, His Tag (MALS verified)
NC1-H5253	Human	Human NCAM-1 / CD56 Protein, Fc Tag (MALS verified)
NC1-H82E3	Human	Biotinylated Human NCAM-1 / CD56 Protein, His,Avitag™ (MALS verified)
NC1-HF256	Human	FITC-Labeled Human NCAM-1 / CD56 Protein, Fc Tag
NC1-HF2H5	Human	FITC-Labeled Human NCAM-1 / CD56 Protein, His Tag
NC1-M52H4	Mouse	Mouse NCAM-1 / CD56 Protein, His Tag

NC1-M52H4|Mouse NCAM-1 / CD56 Protein, His Tag

159XXXXXXX6

0人赞

应用流式抗体，效果正在使用中，一直有订购产品，品牌值得信赖，值得推荐给大家，分享给大家，希望能够有更多合作的机会
2022-10-27

NC1-M52H4|Mouse NCAM-1 / CD56 Protein, His Tag

151XXXXXXX5

0人赞

NKP46靶点淘选后，我们分别进行了人原鼠原猴原的Pe Elisa，所以本次采购鼠原的蛋白是为了获得交叉反应后的优选克隆
2022-12-09

NCAM-1 分子别名

CD56,MSK39,NCAM1,N-CAM-1

NCAM-1 分子背景

NCAM1 belongs to the immunoglobulin superfamily of adhesion molecules. A wide range of alternatively spliced NCAM1 messenger RNAs (mRNAs) has been described to date, but only the 120-, 140-, and 180- kDa isoforms are commonly expressed. NCAM1 plays an important role in the regulation of neurogenesis, neurite outgrowth, proliferation, and cell migration, however, its function in hematopoiesis, including NK cells, is poorly understood. NCAM1 signaling is mediated either by homophilic or heterophilic interactions with fibroblast growth factor receptor (FGFR), L1-CAM, N-cadherin and other components of the extracellular matrix. Upon activation, NCAM1 triggers a variety of signaling cascades including FYN–focal adhesion kinase (FAK), MAPK, and phosphatidylinositol 3-kinase (PI3K) pathways.

NCAM-1 前沿进展

NCAM-1临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Lorvotuzumab mertansine	BB-10901; IMGN-901; huN-901-DM1; IMGN-901-TAP; huN-901-SPP-DM1	临床二期	Immunogen Inc	横纹肌肉瘤, 白血病, 卵巢癌, Merkel细胞癌, 肾母细胞瘤, 小细胞肺癌, 滑膜肉瘤, 多发性骨髓瘤, 神经纤维肉瘤, 神经母细胞瘤, 小细胞癌	详情
GD2/CD56 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute)	bi-4SCAR GD2/CD56	临床二期	深圳市免疫基因治疗研究院	肿瘤	详情

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NCAM-1