登录 | 注册    关注公众号  
搜索

NCAM-1信息

英文名称:Neural cell adhesion molecule 1
中文名称:神经细胞粘附分子-1
靶点别称:Neural cell adhesion molecule 1,CD56,NCAM1,NCAM,Neural Cell Adhesion Molecule, NCAM,CD56 Antigen,N-CAM-1,MSK39,NCAM-1,Antigen Recognized By Monoclonal Antibody 5.1H11
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

NCAM-1 分子别名

CD56,MSK39,NCAM1,N-CAM-1

NCAM-1 分子背景

NCAM1 belongs to the immunoglobulin superfamily of adhesion molecules. A wide range of alternatively spliced NCAM1 messenger RNAs (mRNAs) has been described to date, but only the 120-, 140-, and 180- kDa isoforms are commonly expressed. NCAM1 plays an important role in the regulation of neurogenesis, neurite outgrowth, proliferation, and cell migration, however, its function in hematopoiesis, including NK cells, is poorly understood. NCAM1 signaling is mediated either by homophilic or heterophilic interactions with fibroblast growth factor receptor (FGFR), L1-CAM, N-cadherin and other components of the extracellular matrix. Upon activation, NCAM1 triggers a variety of signaling cascades including FYN–focal adhesion kinase (FAK), MAPK, and phosphatidylinositol 3-kinase (PI3K) pathways.

NCAM-1 前沿进展

NCAM-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
GD2/CD56 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) bi-4SCAR GD2/CD56 临床二期 深圳市免疫基因治疗研究院 肿瘤 详情

消息提示

请输入您的联系方式,再点击提交!

确定