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NOTCH3信息

英文名称:Neurogenic locus notch homolog protein 3
中文名称:神经源性基因座notch同源蛋白-3
靶点别称:Neurogenic Locus Notch Homolog Protein 3,LMNS,Notch 3,NOTCH3,Notch (Drosophila) Homolog 3,Notch Homolog 3 (Drosophila),Notch Homolog 3,CADASIL1,CADASIL,CASIL,IMF2,Receptor, Notch3,Notch Receptor 3
上市药物数量:0
临床药物数量:1
最高研发阶段:临床前

NOTCH3产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
NO3-H5255
Human
Human NOTCH3 Protein, Fc Tag
 
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NOTCH3 分子别名

Notch-3,NOTCH3

NOTCH3 分子背景

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs

NOTCH3 前沿进展

NOTCH3临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Tarextumab OMP-59R5 Oncomed Pharmaceuticals Inc 详情
PF-06650808 PF-6650808; PF-06650808 辉瑞 详情

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