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NOTCH2信息

英文名称:Neurogenic locus notch homolog protein 2
中文名称:神经源性基因座notch同源蛋白-2
靶点别称:N2ECD,NOTCH2,N2ICD,Notch 2,hN2,Neurogenic Locus Notch Homolog Protein 2,Notch (Drosophila) Homolog 2,Notch Homolog 2 (Drosophila),Notch Homolog 2,HJCYS,AGS2,Receptor, Notch2,Notch Receptor 2
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

NOTCH2产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
NO2-H5255
Human
Human NOTCH2 Protein, Fc Tag (MALS verified)
 
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NOTCH2 分子别名

NOTCH2, hN2, N2ECD

NOTCH2 分子背景

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .

NOTCH2 前沿进展

NOTCH2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Tarextumab OMP-59R5 临床二期 Oncomed Pharmaceuticals 实体瘤, 胰腺癌, 小细胞肺癌 详情

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