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ILDR2信息

英文名称:Immunoglobulin-like domain-containing receptor 2
中文名称:免疫球蛋白样结构域受体2
靶点别称:Immunoglobulin-like domain-containing receptor 2,ILDR2,C1orf32,Immunoglobulin-Like Domain Containing Receptor 2,LISCH-Like,DJ782G3.1,Immunoglobulin Like Domain Containing Receptor 2,Chromosome 1 Open Reading Frame 32
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

ILDR2产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
IL2-M52H5
Mouse
Mouse ILDR2 Protein, His Tag
IL2-H5259
Human
Human ILDR2 Protein, Fc Tag
 
评论(1)
IL2-H5259|Human ILDR2 Protein, Fc Tag
  1. 176XXXXXXX6
  2. 0人赞
  3. IL-2-H5259的产品应用了抗体筛选的实验安排中,用于FACS Blocking实验,分选T细胞后,Z0080和Z081最高浓度结合都有2倍多结合窗口,比较了百英的,自备的,ACRO的在用,效果不错;
  4. 2021-09-01
 

ILDR2 分子别名

ILDR2,C1orf32

ILDR2 分子背景

ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.

ILDR2 前沿进展

ILDR2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Bapotulimab BAY-1905254 临床一期 Compugen 头颈部鳞状细胞癌 详情

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