NOTCH1 靶点蛋白|抗体药物|临床药物信息

NOTCH1信息

英文名称：Neurogenic locus notch homolog protein 1
中文名称：神经源性基因Notch同源蛋白1
靶点别称：Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1

上市药物数量：0
临床药物数量：0
最高研发阶段：无进展

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Protein (2)

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Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
NO1-M52H8	Mouse	Mouse NOTCH1 Protein, His Tag
NO1-H5255	Human	Human NOTCH1 Protein, Fc Tag (MALS verified)

NO1-H5255|Human NOTCH1 Protein, Fc Tag (MALS verified)

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2人赞

购买此蛋白用于检测受体和配体之间的结合，建立RBA assay。此蛋白Elisa检测可以和配体很好的结合，在octet上检测和配体的亲和力也符合文献报道。
2021-12-14

NOTCH1 分子别名

NOTCH1,Notch 1,hN1,TAN1

NOTCH1 分子背景

NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

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