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NOTCH1信息

英文名称:Neurogenic locus notch homolog protein 1
中文名称:神经源性基因Notch同源蛋白1
靶点别称:Notch Receptor 1,EC 2.1.2.11,Translocation-associated notch protein TAN-1,NEXT,NICD,hN1,NOTCH1,Notch 1,TAN1,Notch (Drosophila) Homolog 1 (Translocation-Associated),Notch Homolog 1, Translocation-Associated (Drosophila),Notch Homolog 1, Translocation-Associated,AOVD1,AOS5,Receptor, Notch1,EC 3.4.21.68,Neurogenic locus notch homolog protein 1
上市药物数量:0
临床药物数量:0
最高研发阶段:无进展

NOTCH1产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
NO1-M52H8
Mouse
Mouse NOTCH1 Protein, His Tag
NO1-H5255
Human
Human NOTCH1 Protein, Fc Tag (MALS verified)
 
评论(1)
NO1-H5255|Human NOTCH1 Protein, Fc Tag (MALS verified)
  1. 150XXXXXXX1
  2. 2人赞
  3. 购买此蛋白用于检测受体和配体之间的结合,建立RBA assay。 此蛋白Elisa检测可以和配体很好的结合,在octet上检测和配体的亲和力也符合文献报道。
  4. 2021-12-14
 

NOTCH1 分子别名

NOTCH1,Notch 1,hN1,TAN1

NOTCH1 分子背景

NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

NOTCH1 前沿进展

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