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Carbonic Anhydrase II信息

英文名称:Carbonic anhydrase II
中文名称:碳酸酐酶II
靶点别称:Carbonic anhydrase II,Carbonic Anhydrase B,EC:4.2.1.1,Carbonate Dehydratase II,Carbonic Anhydrase C,EC 4.2.1.1,CA2,Epididymis Luminal Protein 76,Car2,HEL-76,Epididymis Secretory Protein Li 282,CA-II,CAC,CAII,HEL-S-282,Carbonic Anhydrase 2,Carbonic Dehydratase
上市药物数量:7
临床药物数量:1
最高研发阶段:批准上市

Carbonic Anhydrase II产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CA2-H5228
Human
Human Carbonic Anhydrase II / CA2 Protein, His Tag
 
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Carbonic Anhydrase II 分子别名

CA2,CA-II,CAII,Car2

Carbonic Anhydrase II 分子背景

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. They are, therefore, classified as metalloenzymes. There are at least five distinct CA families (α, β, γ, δ and ε). These families have no significant amino acid sequence similarity and in most cases are thought to be an example of convergent evolution. The α-CAs are found in humans. Carbonic anhydrase II (CA2) is also known as Carbonate dehydratase II, Carbonic anhydrase C, is one of fourteen forms of human α carbonic anhydrases. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of sodium ions in the proximal tubule. Carbonic anhydrase II has been shown to interact with Band 3 and Sodium-hydrogen antiporter 1.

Carbonic Anhydrase II 前沿进展

Carbonic Anhydrase II上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Brinzolamide/Timolol Maleate 布林佐胺/马来酸噻吗洛尔 批准上市 英国爱尔康公司 Azarga Mainland China 高眼压, 开角型青光眼 Alcon Laboratories (U.K.) Ltd 2008-11-25 开角型青光眼, 高眼压, 青光眼 详情
Brinzolamide 布林佐胺 AL-4862; ALO-4862 批准上市 英国爱尔康公司 派立明, Azopt Japan 高眼压, 开角型青光眼 Alcon 1998-04-01 开角型青光眼, 高眼压 详情
Brinzolamide/Brimonidine Tartrate 布林佐胺/酒石酸溴莫尼定 批准上市 诺华制药 Simbrinza Mainland China 高眼压, 开角型青光眼 Novartis Europharm Ltd 2013-04-19 开角型青光眼, 高眼压 详情
Sultiame 舒噻美 Riker-594 批准上市 Ospolot 癫痫 详情
Topiramate 托吡酯 KW-6485P; McN-4853; RWJ-17021; W-6485; TPM; SPN-538; USL-255 批准上市 杨森 Topamax, Topina, Conviban, Qudexy, Eprontia, 妥泰 United States Lennox Gastaut综合征 Upsher-Smith Laboratories Llc 1995-01-01 赌博, Lennox Gastaut综合征, 强直阵挛性癫痫, 认知, 失神发作, 强迫性障碍, 有先兆的偏头痛, 尼古丁依赖, 多动秽语综合征, 全身性癫痫, 癫痫, 脑缺氧缺血, 酗酒, 高血压, 帕金森病, 创伤后应激障碍, 可卡因成瘾, 饮酒, 无先兆偏头痛, 肥胖症, 淋巴瘤, 高脂血症, 先天性心脏缺损, 精神疾病, 血管性头痛, 精神病性情感障碍,, 狂饮, 酒精引起的疾病, 头痛, HIV感染, 儿童肥胖症, 高甘油三酯血症, 周围神经系统疾病, 体重减轻, 狂饮-进食障碍, 癫痫发作, 癫痫部分性发作, 避孕, 二型糖尿病, 偏头痛, 大麻依赖, 情绪障碍, 躁狂症, 特发性震颤, 戒烟, 糖尿病神经病变, 多发性神经病, 贪食症, X综合征, 病态肥胖, 术后疼痛 详情

Carbonic Anhydrase II临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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