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PSGL-1信息

英文名称:P-selectin glycoprotein ligand-1
中文名称:P选择素糖蛋白配体1
靶点别称:P-selectin glycoprotein ligand 1,PSGL-1,SELPLG,Selectin P Ligand,Cutaneous Lymphocyte-Associated Associated Antigen,CD162 Antigen,CD162,PSGL1,CLA
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

PSGL-1产品列表

 
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PSGL-1 分子别名

PSGL1,CD162,SELPLG,Selectin P ligand

PSGL-1 分子背景

P-selectin glycoprotein ligand 1 (PSGL-1) is also known as Selectin P ligand (SELPLG), CD antigen CD162. PSGL-1 is disulfide-linked homodimer which is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 / SELPLG interacts with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Dimerization appears not to be required for P-selectin/SELP binding. PSGL-1 can interact with SNX20, MSN and SYK. PSGL-1 / SELPLG mediate the activation of SYK by SELPLG.

PSGL-1 前沿进展

PSGL-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
SSGJ-617 SSGJ-617; SSGJ617; 61X; VTX-0811 临床一期 三生国健药业(上海)股份有限公司, Verseau Therapeutics Inc 实体瘤 详情
Neihulizumab AbGn-168; AbGn-168H 临床一期 Abgenomics 移植物抗宿主病, 银屑病, 银屑病关节炎, 溃疡性结肠炎 详情
SelK-2 SelK-2 临床二期 Selexys 静脉血栓栓塞, 哮喘, 慢性阻塞性肺疾病 详情

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