PSGL-1 靶点蛋白|抗体药物|临床药物信息

PSGL-1信息

英文名称：P-selectin glycoprotein ligand-1
中文名称：P选择素糖蛋白配体1
靶点别称：P-selectin glycoprotein ligand 1，PSGL-1，SELPLG，Selectin P Ligand，Cutaneous Lymphocyte-Associated Associated Antigen，CD162 Antigen，CD162，PSGL1，CLA

上市药物数量：0
临床药物数量：4
最高研发阶段：临床二期

PSGL-1产品列表

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产品库

在线 (2)

物种

Human (2)

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属性

Protein (2)

标记

货号	物种	产品描述	蛋白结构	纯度	活性
PS1-H52H9	Human	Human PSGL-1 / CD162 Protein, His Tag
PS1-H82E4	Human	Biotinylated Human PSGL-1 / CD162 Protein, His,Avitag™

PSGL-1 分子别名

PSGL1,CD162,SELPLG,Selectin P ligand

PSGL-1 分子背景

P-selectin glycoprotein ligand 1 (PSGL-1) is also known as Selectin P ligand (SELPLG), CD antigen CD162. PSGL-1 is disulfide-linked homodimer which is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 / SELPLG interacts with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Dimerization appears not to be required for P-selectin/SELP binding. PSGL-1 can interact with SNX20, MSN and SYK. PSGL-1 / SELPLG mediate the activation of SYK by SELPLG.

PSGL-1 前沿进展

PSGL-1临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
ALTB-268	ALTB-268	临床一期	Altrubio Inc	溃疡性结肠炎	详情
Neihulizumab	AbGn-168; AbGn-168H	临床一期	Abgenomics	移植物抗宿主病, 银屑病, 银屑病关节炎, 溃疡性结肠炎	详情
SelK-2	SelK-2	临床二期	Selexys	静脉血栓栓塞, 哮喘, 慢性阻塞性肺疾病	详情
SSGJ-617	SSGJ-617; SSGJ617; 61X; VTX-0811	临床一期	三生国健药业（上海）股份有限公司, Verseau Therapeutics Inc	实体瘤	详情

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PSGL-1