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CD209产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
CD9-H5246
Human
Human CD209 / DC-SIGN Protein, His Tag
 
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CD209 分子别名

DC-SIGN,CD209,DC-SIGN1,CLEC4L

CD209 分子背景

Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.

CD209 前沿进展

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