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EphA4信息

英文名称:Erythropoietin-producing hepatocellular receptor A4
中文名称:EphA4
靶点别称:Ephrin type-A receptor 4,EPH-like kinase 8 (EK8; hEK8),Tyrosine-protein kinase TYRO1,Tyrosine-protein kinase receptor SEK,EPH Receptor A4,TYRO1,HEK8,Tyrosine-Protein Kinase Receptor SEK,Tyrosine-Protein Kinase TYRO1,Ephrin Type-A Receptor 4,EPH-Like Kinase 8,EC 2.7.10.1,EK8,SEK,Receptor Protein-Tyrosine Kinase HEK8,TYRO1 Protein Tyrosine Kinase,EC 2.7.10
上市药物数量:0
临床药物数量:2
最高研发阶段:临床一期

EphA4产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
EP4-H52H8
Human
Human EphA4 Protein, His Tag
ACRO质量管理体系
 
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EphA4分子别名

EphA4,HEK8,SEK,TYRO1,EK8

EphA4分子背景

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

EphA4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
mEphA4-Fc mEphA4-Fc 临床一期 Queensland Brain Institute 神经变性, 神经疾病, 肌萎缩性侧索硬化 详情
E2025 E-2025; E2025 临床一期 Eisai Inc 阿尔茨海默病 详情

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