登录 | 注册    关注公众号  
搜索

EphA4产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
EP4-H52H8
Human
Human EphA4 Protein, His Tag
 
评论(0)
 

EphA4 分子别名

EphA4,HEK8,SEK,TYRO1,EK8

EphA4 分子背景

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

EphA4 前沿进展

消息提示

请输入您的联系方式,再点击提交!

确定