TFPI 靶点蛋白|抗体药物|临床药物信息

TFPI信息

英文名称：Tissue factor pathway inhibitor
中文名称：组织因子通道抑制剂
靶点别称：TFPI，Tissue Factor Pathway Inhibitor，Extrinsic Pathway Inhibitor，TFPI1，LACI，EPI，Anti-Convertin，TFI，Lipoprotein-associated coagulation inhibitor，Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor)

上市药物数量：0
临床药物数量：4
最高研发阶段：临床三期

TFPI产品列表

筛选结果

产品库

在线 (2)

物种

Human (2)

标签

His Tag (2)

属性

Protein (2)

标记

货号	物种	产品描述	蛋白结构	纯度	活性
TFI-H5226	Human	Human TFPI Protein, His Tag (active enzyme)
TFI-H8226	Human	Biotinylated Human TFPI Protein, His Tag, ultra sensitivity (primary amine labeling)

TFI-H5226|Human TFPI Protein, His Tag (active enzyme)

151XXXXXXX5

5人赞

我们是先购买的小规格的Human TFPI蛋白，进行实验之后发现效果不错，于是购买了1mg规格的蛋白，用于后续实验，之后应该会继续选择该蛋白用于后续实验，相较于其他厂家，价格有优势，主要是货期也比较短，非常不错。
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2021-11-08

TFPI 分子别名

TFPI,LACI,TFPI1,EPI,TFI

TFPI 分子背景

Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a Nterminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a Cterminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The Cterminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces.

TFPI 前沿进展

TFPI临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
MG-1113	MG-1113	临床一期	韩国绿十字株式会社	血友病A	详情
KN-057	KN-057	临床二期	苏州康宁杰瑞生物科技有限公司	血友病A, 血友病B	详情
Marstacimab	PF-6741086; PF-06741086	临床三期	辉瑞制药有限公司	血友病A, 血友病B, 出血	详情
Concizumab	NN-7415; mAb-2021; Anti-TFPI; mAbTFPI2021; NNC-172-2021; NNC-0172-2021; NNC-0172-0000-2021	临床三期	诺和诺德制药	血友病A, 血友病B, 出血	详情

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TFPI