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TL1A

TL1A信息

英文名称:Tumor necrosis factor superfamily member 15上市药物数量0
中文名称肿瘤坏死因子超家族成员15临床药物数量10
靶点别称VEGI192A，Vascular Endothelial Cell Growth Inhibitor，TNF Superfamily Ligand TL1A，TNFSF15，Tumor Necrosis Factor (Ligand) Superfamily， Member 15，Vascular Endothelial Growth Inhibitor-192A，VEGI，TL1A，Tumor Necrosis Factor Ligand 1B，TNLG1B，TNF Superfamily Member 15，Tumor Necrosis Factor Superfamily Member 15，TL1，TNF Ligand-Related Molecule 1，Tumor Necrosis Factor Ligand Superfamily Member 15，MGC129934，MGC129935最高研发阶段临床三期
英文名称:Tumor necrosis factor superfamily member 15
中文名称肿瘤坏死因子超家族成员15
靶点别称VEGI192A，Vascular Endothelial Cell Growth Inhibitor，TNF Superfamily Ligand TL1A，TNFSF15，Tumor Necrosis Factor (Ligand) Superfamily， Member 15，Vascular Endothelial Growth Inhibitor-192A，VEGI，TL1A，Tumor Necrosis Factor Ligand 1B，TNLG1B，TNF Superfamily Member 15，Tumor Necrosis Factor Superfamily Member 15，TL1，TNF Ligand-Related Molecule 1，Tumor Necrosis Factor Ligand Superfamily Member 15，MGC129934，MGC129935
上市药物数量0
临床药物数量10
最高研发阶段Phase 3 Clinical

TL1A产品列表

  • 属性

    Protein (13)Cell (4)Kits (2)

  • 产品库

    在线 (19)

  • 物种

    Human (12)Cynomolgus / Rhesus macaque (2)Mouse (3)Rat (1)Rabbit (1)

  • 标签

    His Tag (7)His Tag & Avi Tag (2)- (8)Fc Tag (1)Avi Tag & His Tag (1)

  • 标记

    Unconjugated (10)Biotin-labeled (3)- (6)

共 19 项数据
  • 1
  • 2

TL1A分子背景

TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.

TL1A分子别名

TL1A, VEGI, TNFSF15

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