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SMAC

SMAC信息

英文名称:Diablo homolog, mitochondrial上市药物数量0
中文名称DIABLO蛋白临床药物数量1
靶点别称Direct IAP-binding protein with low pI，Second mitochondria-derived activator of caspase，Smac，Diablo IAP-Binding Mitochondrial Protein最高研发阶段临床一期
英文名称:Diablo homolog, mitochondrial
中文名称DIABLO蛋白
靶点别称Direct IAP-binding protein with low pI，Second mitochondria-derived activator of caspase，Smac，Diablo IAP-Binding Mitochondrial Protein
上市药物数量0
临床药物数量1
最高研发阶段Phase 1 Clinical

SMAC产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

SMAC分子背景

Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

SMAC分子别名

DIABLO,SMAC
  • 分子信息
  • 产品列表