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Serpin A1

Serpin A1信息

英文名称:Alpha-1-antiproteinase上市药物数量2
中文名称α1-抗胰蛋白酶临床药物数量12
靶点别称Alpha-1-antiproteinase，PRO2209，Serpin Family A Member 1，alpha 1-Antitrypsin，Protease Inhibitor 1 (Anti-Elastase)， Alpha-1-Antitrypsin，Alpha-1 Protease Inhibitor，Serpin A1，AAT，PI，Serpin Peptidase Inhibitor Clade A (Alpha-1antiproteinase， Antitrypsin) Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C4，Serpin Peptidase Inhibitor Clade A Member 1，Alpha-1-Antitrypsin Null，Alpha-1 Antitrypsin，Alpha-1-Antitrypsin，Alpha1AT，PRO2275，NNIF，A1A，PI1，Epididymis Secretory Sperm Binding Protein，Serpin Peptidase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C5，A1AT，PRO0684，SPAAT，SERPINA1最高研发阶段批准上市
英文名称:Alpha-1-antiproteinase
中文名称α1-抗胰蛋白酶
靶点别称Alpha-1-antiproteinase，PRO2209，Serpin Family A Member 1，alpha 1-Antitrypsin，Protease Inhibitor 1 (Anti-Elastase)， Alpha-1-Antitrypsin，Alpha-1 Protease Inhibitor，Serpin A1，AAT，PI，Serpin Peptidase Inhibitor Clade A (Alpha-1antiproteinase， Antitrypsin) Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C4，Serpin Peptidase Inhibitor Clade A Member 1，Alpha-1-Antitrypsin Null，Alpha-1 Antitrypsin，Alpha-1-Antitrypsin，Alpha1AT，PRO2275，NNIF，A1A，PI1，Epididymis Secretory Sperm Binding Protein，Serpin Peptidase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Serine (Or Cysteine) Proteinase Inhibitor， Clade A (Alpha-1 Antiproteinase， Antitrypsin)， Member 1，Alpha-1-Antitrypsin Short Transcript Variant 1C5，A1AT，PRO0684，SPAAT，SERPINA1
上市药物数量2
临床药物数量12
最高研发阶段Approved

Serpin A1产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

Serpin A1分子背景

Serpin A1 is also known as Alpha-1-antitrypsin (A1AT), serum trypsin inhibitor, alpha-1 proteinase inhibitor (A1PI), AAT, which belongs to the serpin family. Most serpins inactivate enzymes by binding to them covalently, requiring very high levels to perform their function. Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Serpin A1 / A1AT is inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form of SerpinA1 inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Serpin A1 / A1AT protects tissues from enzymes of inflammatory cells, especially neutrophil elastase. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD).

Serpin A1分子别名

SerpinA1,PI,A1A,AAT,PI1,A1AT,MGC9222,PRO2275,MGC23330,alpha1AT,SPAAT
  • 分子信息
  • 产品列表