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Semaphorin 4D

Semaphorin 4D信息

英文名称:Semaphorin 4D上市药物数量0
中文名称脑信号蛋白4D临床药物数量1
靶点别称SEMAJ，SEMA4D，Semaphorin 4D，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， (Semaphorin) 4D，C9orf164，CD100，BB18，GR3，A8，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， 4D，Chromosome 9 Open Reading Frame 164，CD100 Antigen，M-Sema-G，M-Sema G，Coll-4，COLL4，FLJ39737，Semaphorin-4D最高研发阶段临床二期
英文名称:Semaphorin 4D
中文名称脑信号蛋白4D
靶点别称SEMAJ，SEMA4D，Semaphorin 4D，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， (Semaphorin) 4D，C9orf164，CD100，BB18，GR3，A8，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， 4D，Chromosome 9 Open Reading Frame 164，CD100 Antigen，M-Sema-G，M-Sema G，Coll-4，COLL4，FLJ39737，Semaphorin-4D
上市药物数量0
临床药物数量1
最高研发阶段Phase 2 Clinical

Semaphorin 4D产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    Fc Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

Semaphorin 4D分子背景

Cluster of Differentiation 100 (CD100) is also known as Semaphorin-4D (SEMA4D), is a single-pass type I membrane protein which belongs to the semaphorin family, and is a human 150-kDa homodimer expressed at the surface of most hemopoietic cells. Semaphorin genes encode soluble and membrane-bound proteins, most of which have been shown to act as chemorepellents on growth cone guidance. CD100 is discrete, as it is a transmembrane leukocyte surface molecule that can also exist in a soluble form. Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation. It is involved in oligodendrogenesis during development and during recovery from ischemic injury.

Semaphorin 4D分子别名

SEMA4D,C9orf164,CD100,FLJ33485,FLJ34282,FLJ39737,FLJ46484,M-sema-G,MGC169138,MGC169141,SEMAJ,coll-4,Semaphorin-4D
  • 分子信息
  • 产品列表