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R-Spondin 3

R-Spondin 3信息

英文名称:R-spondin-3上市药物数量0
中文名称R-脊椎蛋白3临床药物数量0
靶点别称Thrombospondin Type-1 Domain-Containing Protein 2，Thrombospondin， Type I， Domain Containing 2，Protein With TSP Type-1 Repeat，PWTSR，R-Spondin 3 Homolog (Xenopus Laevis)，R-Spondin 3 Homolog，R-Spondin-3，CRISTIN1，HRspo3，FLJ14440，Roof plate-specific spondin-3，RSPO3，hPWTSR，THSD2，R-Spondin 3最高研发阶段临床前
英文名称:R-spondin-3
中文名称R-脊椎蛋白3
靶点别称Thrombospondin Type-1 Domain-Containing Protein 2，Thrombospondin， Type I， Domain Containing 2，Protein With TSP Type-1 Repeat，PWTSR，R-Spondin 3 Homolog (Xenopus Laevis)，R-Spondin 3 Homolog，R-Spondin-3，CRISTIN1，HRspo3，FLJ14440，Roof plate-specific spondin-3，RSPO3，hPWTSR，THSD2，R-Spondin 3
上市药物数量0
临床药物数量0
最高研发阶段Preclinical

R-Spondin 3产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (2)

  • 物种

    Human (2)

  • 标签

    His Tag (1)Fc Tag (1)

  • 标记

    Unconjugated (2)

共 2 项数据
  • 1

R-Spondin 3分子背景

R-Spondin 3 (RSPO3) is also called cysteine-rich and single thrombospondin domain containing-1 (CRISTIN1), Protein with TSP type-1 repeat (PWTSR), is a member of the R-spondin protein family. R-spondins (RSPO) are a recently discovered secretory protein family with four members in human and mouse. Although all four RSPO proteins activate the canonical Wnt pathway, RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. RSPO-3 is expressed ubiquitously and expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is the activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO3 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. RSPO3 also acts as a ligand for frizzled FZD8 and LRP6 and may negatively regulate the TGF-beta pathway.

R-Spondin 3分子别名

RSPO3,CRISTIN1,PWTSR,THSD2
  • 分子信息
  • 产品列表