选择语言
免费注册
关注公众号

PSGL-1

PSGL-1信息

英文名称:P-selectin glycoprotein ligand-1上市药物数量0
中文名称P选择素糖蛋白配体1临床药物数量4
靶点别称P-selectin glycoprotein ligand 1，PSGL-1，SELPLG，Selectin P Ligand，Cutaneous Lymphocyte-Associated Associated Antigen，CD162 Antigen，CD162，PSGL1，CLA最高研发阶段临床二期
英文名称:P-selectin glycoprotein ligand-1
中文名称P选择素糖蛋白配体1
靶点别称P-selectin glycoprotein ligand 1，PSGL-1，SELPLG，Selectin P Ligand，Cutaneous Lymphocyte-Associated Associated Antigen，CD162 Antigen，CD162，PSGL1，CLA
上市药物数量0
临床药物数量4
最高研发阶段Phase 2 Clinical

PSGL-1产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (2)

  • 物种

    Human (2)

  • 标签

    His Tag (1)His Tag & Avi Tag (1)

  • 标记

    Unconjugated (1)Biotin-labeled (1)

共 2 项数据
  • 1

PSGL-1分子背景

P-selectin glycoprotein ligand 1 (PSGL-1) is also known as Selectin P ligand (SELPLG), CD antigen CD162. PSGL-1 is disulfide-linked homodimer which is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 / SELPLG interacts with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Dimerization appears not to be required for P-selectin/SELP binding. PSGL-1 can interact with SNX20, MSN and SYK. PSGL-1 / SELPLG mediate the activation of SYK by SELPLG.

PSGL-1分子别名

PSGL1,CD162,SELPLG,Selectin P ligand
  • 分子信息
  • 产品列表