Postfusion glycoprotein F0/post-F protein (HMPV)

Human metapneumovirus (hMPV) is a paramyxovirHMPV G protein has not been shown to possess either hemagglutination or neuraminidase activity. Recombinant HMPV lacking the G protein replicates at levels similar to wild-type virus in vitro, but exhibits reduced titers in v ivo . One report suggested that HMPV G serves as an attachment protein and binds to cell surface glycosaminoglycans and thus may have a true attachment function us that is a common cause of bronchiolitis and pneumonia in children less than five years of age. The hMPV fusion (F) glycoprotein is the primary target of neutralizing antibodiesand is thus a critical vaccine antigen.