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P-Selectin

P-Selectin信息

英文名称:P-selectin上市药物数量1
中文名称P-选择素临床药物数量1
靶点别称Platelet Activation Dependent Granule-External Membrane Protein，Granule Membrane Protein 140kDa，PADGEM，GRMP，Selectin P (Granule Membrane Protein 140kD， Antigen CD62)，Platelet Alpha-Granule Membrane Protein，Granulocyte Membrane Protein，CD62P Antigen，Antigen CD62，P-Selectin，GMP140，CD62P，CD62，PSEL，LECAM3，CD62 antigen-like family member P，GMRP，GMP-140，Granule membrane protein 140，SELP，Selectin P，Selectin P (Granule Membrane Protein 140kDa， Antigen CD62)，Leukocyte-Endothelial Cell Adhesion Molecule 3最高研发阶段批准上市
英文名称:P-selectin
中文名称P-选择素
靶点别称Platelet Activation Dependent Granule-External Membrane Protein，Granule Membrane Protein 140kDa，PADGEM，GRMP，Selectin P (Granule Membrane Protein 140kD， Antigen CD62)，Platelet Alpha-Granule Membrane Protein，Granulocyte Membrane Protein，CD62P Antigen，Antigen CD62，P-Selectin，GMP140，CD62P，CD62，PSEL，LECAM3，CD62 antigen-like family member P，GMRP，GMP-140，Granule membrane protein 140，SELP，Selectin P，Selectin P (Granule Membrane Protein 140kDa， Antigen CD62)，Leukocyte-Endothelial Cell Adhesion Molecule 3
上市药物数量1
临床药物数量1
最高研发阶段Approved

P-Selectin产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (2)

  • 物种

    Human (2)

  • 标签

    His Tag (1)Fc Tag (1)

  • 标记

    Unconjugated (2)

共 2 项数据
  • 1

P-Selectin分子背景

P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets SELP is stored in α-granules. The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.

P-Selectin分子别名

P-Selectin,CD62P,SELP,GMP-140
  • 分子信息
  • 产品列表