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MCAM

MCAM信息

英文名称:Melanoma cell adhesion molecule上市药物数量0
中文名称黑色素瘤细胞粘附分子临床药物数量2
靶点别称METCAM，CD146，Melanoma cell adhesion molecule，MCAM，Cell surface glycoprotein MUC18，S-Endo 1 Endothelial-Associated Antigen，Melanoma-Associated Antigen MUC18，Melanoma-Associated Antigen A32，Gicerin，MUC18，CD146 Antigen，Cell surface glycoprotein P1H12，Melanoma Adhesion Molecule，MelCAM，HEMCAM最高研发阶段临床二期
英文名称:Melanoma cell adhesion molecule
中文名称黑色素瘤细胞粘附分子
靶点别称METCAM，CD146，Melanoma cell adhesion molecule，MCAM，Cell surface glycoprotein MUC18，S-Endo 1 Endothelial-Associated Antigen，Melanoma-Associated Antigen MUC18，Melanoma-Associated Antigen A32，Gicerin，MUC18，CD146 Antigen，Cell surface glycoprotein P1H12，Melanoma Adhesion Molecule，MelCAM，HEMCAM
上市药物数量0
临床药物数量2
最高研发阶段Phase 2 Clinical

MCAM产品列表

  • 属性

    Protein (4)Cell (1)

  • 产品库

    在线 (5)

  • 物种

    Human (2)Mouse (1)Rat (1)Cynomolgus (1)

  • 标签

    His Tag (4)- (1)

  • 标记

    Unconjugated (4)- (1)

共 5 项数据
  • 1

MCAM分子背景

CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

MCAM分子别名

MCAM,CD146,MUC18
  • 分子信息
  • 产品列表