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LOXL2

LOXL2信息

英文名称:Lysyl oxidase homolog 2上市药物数量0
中文名称赖氨酰氧化酶同源蛋白-2临床药物数量3
靶点别称EC:1.4.3.13，EC 1.4.3，Lysyl oxidase-like protein 2，Lysyl oxidase homolog 2，LOXL2，Lysyl Oxidase Like 2，Lysyl Oxidase-Related Protein WS9-14，Lysyl Oxidase-Related Protein 2，Lysyl Oxidase-Like 2 Delta E13，Lysyl Oxidase-Like 2 Protein，Lysyl Oxidase Related 2，Lysyl Oxidase-Like 2，EC 1.4.3.13，WS9-14，LOR2，LOR最高研发阶段临床二期
英文名称:Lysyl oxidase homolog 2
中文名称赖氨酰氧化酶同源蛋白-2
靶点别称EC:1.4.3.13，EC 1.4.3，Lysyl oxidase-like protein 2，Lysyl oxidase homolog 2，LOXL2，Lysyl Oxidase Like 2，Lysyl Oxidase-Related Protein WS9-14，Lysyl Oxidase-Related Protein 2，Lysyl Oxidase-Like 2 Delta E13，Lysyl Oxidase-Like 2 Protein，Lysyl Oxidase Related 2，Lysyl Oxidase-Like 2，EC 1.4.3.13，WS9-14，LOR2，LOR
上市药物数量0
临床药物数量3
最高研发阶段Phase 2 Clinical

LOXL2产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (1)在研 (1)

  • 物种

    Human (2)

  • 标签

    His Tag & Avi Tag (1)His Tag (1)

  • 标记

    Biotin-labeled (1)Unconjugated (1)

共 2 项数据
  • 1

LOXL2分子背景

Lysyl oxidase homolog 2 is also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

LOXL2分子别名

Lysyl oxidase homolog 2,LOXL2
  • 分子信息
  • 产品列表