LC3B

LC3B is a pivotal protein encoded by the MAP1LC3B gene, widely recognized as a core component and indicator of cellular autophagy. It plays an essential role in autophagosome formation and the regulation of the autophagic degradation pathway. Critically, the conversion of cytosolic LC3B-I to lipidated, autophagosome-associated LC3B-II upon autophagy activation serves as a robust and widely used biochemical hallmark for assessing autophagic activity.