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IGF-I R

IGF-I R信息

英文名称:Insulin-like growth factor I receptor上市药物数量7
中文名称胰岛素样生长因子-I受体临床药物数量24
靶点别称IGF-I receptor,IGF1R,Insulin Like Growth Factor 1 Receptor,Insulin-Like Growth Factor 1 Receptor,Insulin-Like Growth Factor I Receptor,Soluble IGF1R Variant 1,Soluble IGF1R Variant 2,CD221 Antigen,CD221,IGFIR,JTK13,IGFR,Receptor, IGF Type 1,MGC18216最高研发阶段批准上市
英文名称:Insulin-like growth factor I receptor
中文名称胰岛素样生长因子-I受体
靶点别称IGF-I receptor,IGF1R,Insulin Like Growth Factor 1 Receptor,Insulin-Like Growth Factor 1 Receptor,Insulin-Like Growth Factor I Receptor,Soluble IGF1R Variant 1,Soluble IGF1R Variant 2,CD221 Antigen,CD221,IGFIR,JTK13,IGFR,Receptor, IGF Type 1,MGC18216
上市药物数量7
临床药物数量24
最高研发阶段Approved

IGF-I R产品列表

  • 属性

    Protein (8)Cell (2)

  • 产品库

    在线 (10)

  • 物种

    Mouse (2)Rat (1)Cynomolgus (2)Human (5)

  • 标签

    His Tag (5)His Tag & Avi Tag (1)Fc Tag (2)- (2)

  • 标记

    Unconjugated (6)Biotin-labeled (2)- (2)

共 10 项数据
  • 1

IGF-I R分子背景

The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.

IGF-I R分子别名

IGF1R,IGFR,JTK13,CD221,MGC142170,MGC142172,MGC18216

产品评论

  • 18********qq.com 2025-06-30
    0人点赞
    已经是二次回购Cynomolgus CD221蛋白,因为质量稳定,CD221靶点相关蛋白我们都会选择ACRO的,不管用于竞争性筛选,还是抗体活性检测,拿到的数据一致性都非常帮,而且批间差异小,很值得信赖。
  • 18********qq.com 2025-06-30
    0人点赞
    购买Mouse CD221重组蛋白,主要用于纳米抗体的生物淘筛,与人的CD221相比,其同源性较低,筛选富集速度相对较慢,但富集克隆多样性高,而且亲和力也很不错,很值得回购。
  • 18********qq.com 2025-06-30
    0人点赞
    本次同时采购了人和小鼠的CD221蛋白,主要用于纳米抗体库的生物淘筛。蛋白活性都很稳定,通过交叉筛选成功获得了多个高亲和力阳性抗体,后期还会使用该蛋白作进一步活性验证,期待EC50能够达到预期目标。
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