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IDH1

IDH1信息

英文名称:Isocitrate dehydrogenase [NADP] cytoplasmic上市药物数量3
中文名称细胞质异柠檬酸脱氢酶[NADP]临床药物数量12
靶点别称IDH，EC 1.1.1.42，PICD，IDCD，Isocitrate Dehydrogenase (NADP(+)) 1，Isocitrate Dehydrogenase 1 (NADP+)， Soluble，HEL-S-26，IDH1，Isocitrate Dehydrogenase (NADP(+)) 1， Cytosolic，HEL-216，NADP(+)-Specific ICDH，Cytosolic NADP-Isocitrate Dehydrogenase，IDP，NADP-Dependent Isocitrate Dehydrogenase， Cytosolic，Oxalosuccinate Decarboxylase，Epididymis Secretory Protein Li 26，Isocitrate Dehydrogenase 1 (NADP+)，NADP-Dependent Isocitrate Dehydrogenase， Peroxisomal，IDPC，EC:1.1.1.42，Epididymis Luminal Protein 216，Epididymis Secretory Sperm Binding Protein，Isocitrate Dehydrogenase [NADP] Cytoplasmic最高研发阶段批准上市
英文名称:Isocitrate dehydrogenase [NADP] cytoplasmic
中文名称细胞质异柠檬酸脱氢酶[NADP]
靶点别称IDH，EC 1.1.1.42，PICD，IDCD，Isocitrate Dehydrogenase (NADP(+)) 1，Isocitrate Dehydrogenase 1 (NADP+)， Soluble，HEL-S-26，IDH1，Isocitrate Dehydrogenase (NADP(+)) 1， Cytosolic，HEL-216，NADP(+)-Specific ICDH，Cytosolic NADP-Isocitrate Dehydrogenase，IDP，NADP-Dependent Isocitrate Dehydrogenase， Cytosolic，Oxalosuccinate Decarboxylase，Epididymis Secretory Protein Li 26，Isocitrate Dehydrogenase 1 (NADP+)，NADP-Dependent Isocitrate Dehydrogenase， Peroxisomal，IDPC，EC:1.1.1.42，Epididymis Luminal Protein 216，Epididymis Secretory Sperm Binding Protein，Isocitrate Dehydrogenase [NADP] Cytoplasmic
上市药物数量3
临床药物数量12
最高研发阶段Approved

IDH1产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (2)

  • 物种

    Human (2)

  • 标签

    His Tag (2)

  • 标记

    Unconjugated (2)

共 2 项数据
  • 1

IDH1分子背景

The IDH enzymes catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (α-KG), producing nicotinamide adenine dinucleotide phosphate (NADPH) in the process via the citric acid cycle. Eukaryotic cells express two distinct classes of IDHs that utilize either NAD or NADP as their cofactors and serve diverse biological functions. NAD-dependent IDH is localized to the mitochondrial matrix and is well known for its central role for energy production in the Krebs cycle. NADP-dependent IDHs are primarily located either in mitochondria or cytoplasm . Each NADP-dependent isozyme is a homodimer. Mutations of Arg132 of human IDH1 result in a reduced ability of the enzyme to convert isocitrate to alpha ‑ketoglutarate, but the enzyme acquires the ability to generate 2-hydroxyglutarate (2HG) from alpha‑ketoglutarate，2-HG is elevated in several tumor types, including a subset of AMLs.

IDH1分子别名

IDH1,PICD,IDP
  • 分子信息
  • 产品列表