HLA-DRA1*0101 & HLA-DRB1*1501 & MBP(ENPVVHFFKNIVTPR)

The peptide ENPVVHFFKNIVTPR, derived from myelin basic protein (MBP), is presented by the MHC class II heterodimer HLA-DRA1*01:01/HLA-DRB1*15:01. This specific peptide-MHC II complex is a predominant autoantigen target in multiple sclerosis (MS) and is strongly associated with the HLA-DRB1*15:01 genetic risk allele. Its recognition by autoreactive CD4⁺ T helper cells initiates and drives the inflammatory immune response against the myelin sheath in the central nervous system, making it a prototypical complex for studying autoimmune demyelination and MS pathogenesis.