HLA-A*0201 & B2M & insB (HLVEALYLV)

Insulin is a heterodimer formed by connecting the A chain (21 amino acids) and B chain (30 amino acids) through two disulfide bonds (A7-B7, A20-B19). Its three-dimensional structure presents a compact spherical conformation. HLVEALYLV is located at amino acids 10-18 of the B chain, and stabilizes the binding interface between insulin and IR through hydrophobic interactions. By regulating the conformation of insulin, it affects its interaction with downstream signaling molecules. The Human HLA-A*0201 & B2M & insB (HLVEALYLV) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and HLVEALYLV peptide of the insB.