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FUS

FUS信息

英文名称:RNA-binding protein FUS上市药物数量0
中文名称临床药物数量1
靶点别称75 kDa DNA-pairing protein，Fused in Sarcoma protein，Translocated in liposarcoma protein，POMp75，Oncogene TLS，Oncogene FUS最高研发阶段临床三期
英文名称:RNA-binding protein FUS
中文名称
靶点别称75 kDa DNA-pairing protein，Fused in Sarcoma protein，Translocated in liposarcoma protein，POMp75，Oncogene TLS，Oncogene FUS
上市药物数量0
临床药物数量1
最高研发阶段Phase 3 Clinical

FUS产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag & MBP Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

FUS分子背景

FUS (RNA-binding protein FUS) is a DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. It binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. It binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. FUS plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, FUS plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis.

FUS分子别名

75 kDa DNA-pairing protein,ALS6,amyotrophic lateral sclerosis 6,FUS1,fused in sarcoma,fus-like protein,Oncogene FUS,Oncogene TLS,RNA-binding protein FUS,POMP75,Translocated in liposarcoma,Translocated in liposarcoma protein
  • 产品列表