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Frizzled-2

Frizzled-2信息

英文名称:Frizzled-2上市药物数量0
中文名称卷曲蛋白-2临床药物数量1
靶点别称Frizzled Class Receptor 2，Frizzled 2， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 2，FzE2，Fz-2最高研发阶段临床一期
英文名称:Frizzled-2
中文名称卷曲蛋白-2
靶点别称Frizzled Class Receptor 2，Frizzled 2， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 2，FzE2，Fz-2
上市药物数量0
临床药物数量1
最高研发阶段Phase 1 Clinical

Frizzled-2产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (2)

  • 物种

    Human (2)

  • 标签

    Fc Tag (2)

  • 标记

    Unconjugated (2)

共 2 项数据
  • 1

Frizzled-2分子背景

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

Frizzled-2分子别名

FZD2,Frizzled-2,Fz-2,hFz2,FzE2
  • 分子信息
  • 产品列表